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Direct Observation of Competing Prion Protein Fibril Populations with Distinct Structures and Kinetics

20 Feb 2023

Abstract excerpt

In prion diseases, fibrillar assemblies of misfolded prion protein (PrP) self-propagate by incorporating PrP monomers. These assemblies can evolve to adapt to changing environments and hosts, but the mechanism of prion evolution is poorly understood. We show that PrP fibrils exist as a population of competing conformers, which are selectively amplified under different conditions and can "mutate" during...

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PMID: 36802500
DOI: 10.1021/acsnano.2c12009

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