Article

The cholesterol 24-hydroxylase enzyme, CYP46A1, reduces overexpressed alpha-synuclein proteins in human cellular models of Parkinson’s disease.

2024-07-03

Abstract excerpt

<title>Abstract</title> <p>A growing body of evidence suggests a correlation between cholesterol metabolism and the pathogenesis of Parkinson's disease (PD). We and others have demonstrated that the activation of the cholesterol 24-hydroxylase enzyme, CYP46A1, responsible for converting cholesterol to 24S-hydroxycholesterol (24-OHC) in the brain, is an effective therapeutic strategy for several neurodegenerative...

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Literature Corpus work: 54738a4c-f6f5-55fd-bf2c-e04aaa2b9c4c
DOI: 10.21203/rs.3.rs-4580957/v1

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