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Article

CYP46A1 variants influence Alzheimer's disease risk and brain cholesterol metabolism.

European psychiatry : the journal of the Association of European Psychiatrists - 1 Apr 2009

Kölsch Heike, Lütjohann Dieter, Jessen Frank, Popp Julius, Hentschel Frank, Kelemen Peter, Schmitz Sandra, Maier Wolfgang, Heun Reinhard

Abstract excerpt

BACKGROUND: Cholesterol 24S-hydroxylase (CYP46) catalyzes the conversion of cholesterol to 24S-hydroxycholesterol, the primary cerebral cholesterol elimination product. Only few gene variations in CYP46 gene (CYP46A1) have been investigated for their relevance as genetic risk factors of Alzheimer's disease (AD) and results are contradictory. METHODS: We performed a gene variability screening in CYP46A1 and...

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Identifiers

PMID: 19286353
DOI: 10.1016/j.eurpsy.2008.12.005

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