Article

Long-term oral regimen of glucocerebrosidase activator reduces a-synuclein oligomer accumulation in aged LRRK2 mutant mouse brains - therapeutic implication of Parkinson’s disease

2025-07-29

Abstract excerpt

<title>Abstract</title> <p> Deposition of misfolded a-synuclein (a-syn) aggregates in brain is a pathological hallmark of Parkinson’s disease (PD). Accumulation of toxic soluble a-syn seeds in patient cerebrospinal fluid represents a prodromal marker of synucleinopathies in PD, contributing to progressive neurodegeneration. Deficiency in beta-glucocerebrosidase (GCase), a lysosomal enzyme for glucocerebroside me...

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Literature Corpus work: b9d50d22-0dce-5144-9f64-ec486f4e7bae
DOI: 10.21203/rs.3.rs-7185990/v1

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