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Article

The Role of PGC1α in Alzheimer’s Disease and Therapeutic Interventions

28 May 2021

Abstract excerpt

The peroxisome proliferator-activated receptor co-activator-1α (PGC1α) belongs to a family of transcriptional regulators, which act as co-activators for a number of transcription factors, including PPARs, NRFs, oestrogen receptors, etc. PGC1α has been implicated in the control of mitochondrial biogenesis, the regulation of the synthesis of ROS and inflammatory cytokines, as well as genes controlling metabolic...

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PMID: 34071270
DOI: 10.3390/ijms22115769

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