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Article

CYP46A1 protects against NMDA-mediated excitotoxicity in Huntington's disease: Analysis of lipid raft content.

Biochimie - 1 Oct 2018

Boussicault Lydie, Kacher Radhia, Lamazière Antonin, Vanhoutte Peter, Caboche Jocelyne, Betuing Sandrine, Potier Marie-Claude

Abstract excerpt

Huntington's Disease (HD) is an autosomal dominant neurodegenerative disease caused by abnormal polyglutamine expansion in huntingtin (mHtt) protein leading to degeneration of striatal neurons. Excitotoxicity, consecutive to overstimulation of N-methyl d-aspartate receptors (NMDARs) has a pivotal role in many neurological disorders including HD. Mutant Htt causes enhanced NMDA sensitivity, alteration of NMDAR...

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Identifiers

PMID: 30107216
DOI: 10.1016/j.biochi.2018.07.019

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