Article

Lysine Acetyltransferase 8-Mediated Histone Acetylation Regulated by GBA1 is Associated with Lysosomal Function Related to α-Synuclein Pathology

2025-06-30

Abstract excerpt

<title>Abstract</title> <p>Lysosomal defects are closely linked to Parkinson’s disease (PD). Mutations in the GBA1 gene, encoding the lysosomal enzyme glucocerebrosidase (GCase), are major genetic risk factors for PD. GBA1 deficiency causes lysosomal dysfunction, leading to α-synuclein (α-syn) accumulation and PD progression. However, the underlying mechanisms remain unclear. In this study, we identified a novel...

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Literature Corpus work: 9ade59d0-9e44-5754-bfd6-4058fbad3e13
DOI: 10.21203/rs.3.rs-6859677/v1

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