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Article

The impairment of cholesterol metabolism in Huntington disease.

Biochimica et biophysica acta - 1 Aug 2015

Leoni Valerio, Caccia Claudio

Abstract excerpt

Huntington disease (HD), an autosomal dominant neurodegenerative disorder caused by an abnormal expansion of CAG trinucleotide repeat in the Huntingtin (HTT) gene, is characterized by extensive neurodegeneration of striatum and cortex and severe diffuse atrophy at MRI. The expression of genes involved in the cholesterol biosynthetic pathway and the amount of cholesterol, lanosterol, lathosterol and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25596342
DOI: 10.1016/j.bbalip.2014.12.018

Genes

HTT
ABCG1
ABCG4
MBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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