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Article

An intronic CYP46A1 polymorphism is associated with Alzheimer disease in a Chinese Han population.

Journal of molecular neuroscience : MN - 1 Jul 2012

He Xiao-ming, Zhang Zhen-xin, Zhang Jun-Wu, Zhou Yong-tao, Wu Cheng-bin, Tang Mou-ni, Hong Zhen

Abstract excerpt

Excess cholesterol is removed from the brain via hydroxylation mediated by cholesterol 24S-hydroxylase (CYP46), which is a mechanism of maintaining cholesterol homeostasis in the brain. The CYP46A1 gene has been suggested as a genetic risk factor for sporadic late-onset Alzheimer's disease (AD). In this report, we analyzed an intronic CYP46A1 single nucleotide polymorphism (SNP) in 508 sporadic AD patients and...

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Identifiers

PMID: 22528464
DOI: 10.1007/s12031-012-9778-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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