Cyp46 polymorphisms in Alzheimer's disease: a review.

doi:10.1007/s12031-009-9227-2

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Article

Cyp46 polymorphisms in Alzheimer's disease: a review.

Journal of molecular neuroscience : MN - 1 Nov 2009

Garcia Anália Nusya Medeiros, Muniz Maria Tereza Cartaxo, Souza e Silva Hugo Rafael, da Silva Helker Albuquerque, Athayde-Junior Luiz

Abstract excerpt

Increasing research findings argue for a link between brain cholesterol turnover and Alzheimer's disease (AD). High cerebral levels of this lipid increase Ass load. The elimination of cerebral cholesterol involves two mechanisms, dependent of apolipoprotein E and cholesterol 24-hydroxylase (CYP46). CYP46 is a gene associated with AD; the most studied single nucleotide polymorphism is the rs754203, which changes...

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PMID: 19705089
DOI: 10.1007/s12031-009-9227-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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