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Article

Overexpression of human E46K mutant α-synuclein impairs macroautophagy via inactivation of JNK1-Bcl-2 pathway.

Molecular neurobiology - 1 Oct 2014

Yan Jia-Qing, Yuan Yu-He, Gao Yan-Na, Huang Ju-Yang, Ma Kai-Li, Gao Yan, Zhang Wan-Qing, Guo Xiao-Feng, Chen Nai-Hong

Abstract excerpt

Parkinson's disease (PD) is pathologically characterized by selective loss of dopaminergic neurons in the midbrain and the existence of intracellular protein inclusions termed Lewy bodies, largely composed of α-synuclein. Genetic studies have revealed that rare point mutations in the gene encodin...

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PMID: 24833599
DOI: 10.1007/s12035-014-8738-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24833599-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Overexpression of human E46K mutant α-synuclein impairs macroautophagy via inactivation of JNK1-Bcl-2 pathway.PMID 24833599Read ↗

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