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Article

Analysis of NHEJ-Based DNA Repair after CRISPR-Mediated DNA Cleavage.

International journal of molecular sciences - 15 Jun 2021

Song Beomjong, Yang Soyeon, Hwang Gue-Ho, Yu Jihyeon, Bae Sangsu

Abstract excerpt

Genome editing using CRISPR-Cas9 nucleases is based on the repair of the DNA double-strand break (DSB). In eukaryotic cells, DSBs are rejoined through homology-directed repair (HDR), non-homologous end joining (NHEJ) or microhomology-mediated end joining (MMEJ) pathways. Among these, it is thought that the NHEJ pathway is dominant and occurs throughout a cell cycle. NHEJ-based DSB repair is known to be...

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Identifiers

PMID: 34203807
DOI: 10.3390/ijms22126397
PMCID: PMC8232687

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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