Article

Loss of Endothelial HIF-Prolyl hydroxylase 2 (PHD2) Induces Cardiac Hypertrophy and Fibrosis

2021-03-20

Abstract excerpt

<h4>Background</h4> Cardiac hypertrophy and fibrosis are common adaptive responses to injury and stress, eventually leading to heart failure. Hypoxia signaling is important to the (patho)physiological process of cardiac remodeling. However, the role of endothelial Prolyl-4 hydroxylase 2 (PHD2)/hypoxia inducible factors (HIFs) signaling in the pathogenesis of heart failure remains elusive. <h4>Methods and Results<...

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Literature Corpus work: 54272f48-eb82-50f5-9799-c24d7cf26e78
DOI: 10.1101/2021.03.19.434301

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