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Article

Ablation of endothelial prolyl hydroxylase domain protein-2 promotes renal vascular remodelling and fibrosis in mice.

Journal of cellular and molecular medicine - 1 Sept 2017

Wang Shuo, Zeng Heng, Chen Sean T, Zhou Liying, Xie Xue-Jiao, He Xiaochen, Tao Yong-Kang, Tuo Qin-Hui, Deng Changqin, Liao Duan-Fang, Chen Jian-Xiong

Abstract excerpt

Accumulating evidence demonstrates that hypoxia-inducible factor (HIF-α) hydroxylase system has a critical role in vascular remodelling. Using an endothelial-specific prolyl hydroxylase domain protein-2 (PHD2) knockout (PHD2EC KO) mouse model, this study investigates the regulatory role of endothelial HIF-α hydroxylase system in the development of renal fibrosis. Knockout of PHD2 in EC up-regulated the expression...

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Identifiers

PMID: 28266128
DOI: 10.1111/jcmm.13117
PMCID: PMC5571552

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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