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Article

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure.

Blood - 15 Mar 2008

Minamishima Yoji Andrew, Moslehi Javid, Bardeesy Nabeel, Cullen Darragh, Bronson Roderick T, Kaelin William G

Abstract excerpt

Pharmacologic activation of the heterodimeric HIF transcription factor appears promising as a strategy to treat diseases, such as anemia, myocardial infarction, and stroke, in which tissue hypoxia is a prominent feature. HIF accumulation is normally linked to oxygen availability because an oxygen-dependent posttranslational modification (prolyl hydroxylation) marks the HIFalpha subunit for polyubiquitination and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hypoxia-Inducible Factor-Proline Dioxygenases

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Source

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Identifiers

PMID: 18096761
DOI: 10.1182/blood-2007-10-117812
PMCID: PMC2265460

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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