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Article

Meox1 accelerates myocardial hypertrophic decompensation through Gata4

15 Nov 2017

Abstract excerpt

Aims: Pathological hypertrophy is the result of gene network regulation, which ultimately leads to adverse cardiac remodelling and heart failure (HF) and is accompanied by the reactivation of a 'foetal gene programme'. The Mesenchyme homeobox 1 (Meox1) gene is one of the foetal programme genes. Meox1 may play a role in embryonic development, but its regulation of pathological hypertrophy is not known. Therefore,...

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PMID: 29155983
DOI: 10.1093/cvr/cvx222

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