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Article

Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system.

Circulation - 14 Aug 2007

Takeda Kotaro, Cowan Ann, Fong Guo-Hua

Abstract excerpt

BACKGROUND: Prolyl hydroxylase domain (PHD) proteins, including PHD1, PHD2, and PHD3, mediate oxygen-dependent degradation of hypoxia-inducible factor (HIF)-alpha subunits. Although angiogenic roles of hypoxia-inducible factors are well known, the roles of PHDs in the vascular system remain to be established. METHODS AND RESULTS: We evaluated angiogenic phenotypes in mice carrying targeted disruptions in genes...

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Identifiers

PMID: 17646578
DOI: 10.1161/CIRCULATIONAHA.107.701516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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