Article

A phenotypic screen identified KEAP1-kelch domain blockade as a mechanism to restore cardiac function in the setting of chronic severe hemodynamic stress

2025-09-26

Abstract excerpt

A bespoke gene expression (GE) based small molecule screen in human induced pluripotent stem cell derived cardiomyocytes (iPSC-CM) was conducted with the aim of identifying drug targets and pathways with the potential to reverse heart failure (HF) pathologic GE and the resultant decompensated HF phenotype. The screen utilized a composite human-murine HF gene expression signature, a target annotated compound set, a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 012f391c-6bcd-55f8-917d-95546d219131
DOI: 10.1101/2025.09.24.678104

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A phenotypic screen identified KEAP1-kelch domain blockade as a mechanism to restore cardiac function in the setting of chronic severe hemodynamic stressDOI 10.1101/2025.09.24.678104Read

Identification of candidate biomarkers and therapeutic agents for heart failure by bioinformatics analysisSemantic proximity Read

Histone lysine demethylase inhibition is a disease-modifying therapy for hypertrophic cardiomyopathySemantic proximity Read

Identification of candidate biomarkers and therapeutic agents for heart failure by bioinformatics analysis.Semantic proximity Read

Integrative single-cell and genetic profiling of human heart failure identifies targets for cardiomyocyte restorationSemantic proximity Read

Molecular Network Analysis and Effector Gene Prioritization of Endurance Training–Influenced Modulation of Cardiac AgingSemantic proximity Read

Gene expression profiles, potential targets and treatments of cardiac remodelingSemantic proximity Read

Senescence and DNA Damage–Induced Inflammation Drive Heart Failure with Preserved Ejection Fraction in Cardiovascular Kidney Metabolic SyndromeSemantic proximity Read

Functional High Throughput Drug Screening Reveals Cyproheptadine as a Novel Treatment for <i>LMNA</i> -related CardiomyopathySemantic proximity Read

Deconvoluting Kinase Inhibitor Induced CardiotoxicitySemantic proximity Read

A personalized, multi-omics approach identifies genes involved in cardiac hypertrophy and heart failureSemantic proximity Read

Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction: A Multiorgan Roadmap.Semantic proximity Read

Therapeutic potential of Relaxin-2 in Heart Failure with preserved Ejection Fraction (HFpEF)Semantic proximity Read