Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Muscle RING finger-1 promotes a maladaptive phenotype in chronic hypoxia-induced right ventricular remodeling.

PloS one - 1 Jan 2014

Campen Matthew J, Paffett Michael L, Colombo E Sage, Lucas Selita N, Anderson Tamara, Nysus Monique, Norenberg Jeffrey P, Gershman Ben, Hesterman Jacob, Hoppin Jack, Willis Monte

Abstract excerpt

Exposure to chronic hypoxia (CH) induces elevated pulmonary artery pressure/resistance, leading to an eventual maladaptive right ventricular hypertrophy (RVH). Muscle RING finger-1 (MuRF1) is a muscle-specific ubiquitin ligase that mediates myocyte atrophy and has been shown to play a role in left ventricular hypertrophy and altered cardiac bioenergetics in pressure overloaded hearts. However, little is known...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Hypoxia
Share to Heart Ventricles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematocrit

Share to Hypertension, Pulmonary

Share to Muscle Proteins

Share to Regional Blood Flow

Share to Tripartite Motif Proteins

Share to Ventricular Remodeling

Source

Open in PubMed Open full text

Identifiers

PMID: 24811453
DOI: 10.1371/journal.pone.0097084
PMCID: PMC4014601

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Muscle RING finger-1 promotes a maladaptive phenotype in chronic hypoxia-induced right ventricular remodeling.PMID 24811453Read ↗

Transcriptomic profiles reveal differences between the right and left ventricle in normoxia and hypoxiaSemantic proximity Read ↗

Transcriptomic Signature of Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension: Deep Sequencing Demonstrates Mitochondrial, Fibrotic, Inflammatory and Angiogenic AbnormalitiesSemantic proximity Read ↗

RV-specific Targeting of Snai1 Rescues Pulmonary Hypertension-induced Right Ventricular Failure by Inhibiting EndMT and Fibrosis <i>via</i> LOXL2 Mediated MechanismSemantic proximity Read ↗

Molecular Signature of a Right Heart Failure Program in Chronic Severe Pulmonary HypertensionSemantic proximity Read ↗

EGR1 Is Implicated in Right Ventricular Cardiac Remodeling Associated with Pulmonary HypertensionSemantic proximity Read ↗

Right Heart Phenotype in Heart Failure With Preserved Ejection Fraction.Semantic proximity Read ↗

Deep phenotyping the right ventricle to establish translational MRI biomarkers for characterization of adaptive and maladaptive states in pulmonary hypertension.Semantic proximity Read ↗

Chronic carvedilol treatment partially reverses the right ventricular failure transcriptional profile in experimental pulmonary hypertensionSemantic proximity Read ↗

Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension.Semantic proximity Read ↗

Dynamic microRNA expression during the transition from right ventricular hypertrophy to failureSemantic proximity Read ↗

Towards a re-definition of 'cardiac hypertrophy' through a rational characterization of left ventricular phenotypes: a position paper of the Working Group 'Myocardial Function' of the ESC.Semantic proximity Read ↗

Loss of Endothelial HIF-Prolyl hydroxylase 2 (PHD2) Induces Cardiac Hypertrophy and FibrosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.