Article

A Novel ARNT-Dependent HIF-2α Signaling as a Protective Mechanism for Cardiac Microvascular Barrier Integrity and Heart Function Post-Myocardial Infarction

2023-03-14

Abstract excerpt

<h4>ABSTRACT</h4> Myocardial infarction (MI) significantly compromises the integrity of the cardiac microvascular endothelial barrier, leading to enhanced leakage and inflammation that contribute to the progression of heart failure. While HIF2α is highly expressed in cardiac endothelial cells (ECs) under hypoxic conditions, its role in regulating microvascular endothelial barrier function during MI is not well un...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 338c6b87-5375-5513-b05c-ac456bc4c175
DOI: 10.1101/2023.03.12.532316

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Novel ARNT-Dependent HIF-2α Signaling as a Protective Mechanism for Cardiac Microvascular Barrier Integrity and Heart Function Post-Myocardial InfarctionDOI 10.1101/2023.03.12.532316Read

Loss of Endothelial HIF-Prolyl hydroxylase 2 (PHD2) Induces Cardiac Hypertrophy and FibrosisSemantic proximity Read

Transcriptome analysis of cardiac endothelial cells after myocardial infarction reveals temporal changes and long-term deficitsSemantic proximity Read

Endothelial cell dysfunction in cardiac disease: driver or consequence?Semantic proximity Read

The lncRNA Malat1 regulates microvascular function after myocardial infarction in mice via miR-26b-5p/Mfn1 axis-mediated mitochondrial dynamicsSemantic proximity Read

Multi-species meta-analysis identifies transcriptional signatures associated with cardiac endothelial responses in the ischaemic heartSemantic proximity Read

EGR2 is a hub-gene in myocardial infarction and aggravates inflammation and apoptosis in hypoxia-induced cardiomyocytesSemantic proximity Read

Hypoxia-inducible factor controls immunoregulatory properties of myeloid cells in mouse cardiac allografts - an experimental study.Semantic proximity Read

A promising field: regulating imbalance of EndMT in cardiovascular diseases.Semantic proximity Read

Effects of Post-Myocardial Infarction Heart Failure on the Bone Vascular NicheSemantic proximity Read

Hypoxia-Inducible Factor-1 Alpha in the HeartSemantic proximity Read

Snail Is a Direct Target of Hypoxia-inducible Factor 1α (HIF1α) in Hypoxia-induced Endothelial to Mesenchymal Transition of Human Coronary Endothelial CellsSemantic proximity Read

Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targetsSemantic proximity Read