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Article

Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy.

Circulation - 7 Sept 2010

Moslehi Javid, Minamishima Yoji Andrew, Shi Jianru, Neuberg Donna, Charytan David M, Padera Robert F, Signoretti Sabina, Liao Ronglih, Kaelin William G

Abstract excerpt

BACKGROUND: Ischemic cardiomyopathy is the major cause of heart failure and a significant cause of morbidity and mortality. The degree of left ventricular dysfunction in this setting is often out of proportion to the amount of overtly infarcted tissue, and how decreased delivery of oxygen and nut...

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Share to Cell Hypoxia
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Hypoxia-Inducible Factor-Proline Dioxygenases

Share to Myocytes, Cardiac

Share to Neovascularization, Physiologic

Share to Procollagen-Proline Dioxygenase

Source

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Identifiers

PMID: 20733101
DOI: 10.1161/CIRCULATIONAHA.109.922427
PMCID: PMC2971656

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20733101-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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