Article

Conditional deletion of human STN1 leads to telomere dysfunction and telomerase-dependent genome instability and proliferation defects

2025-08-07

Abstract excerpt

<h4>ABSTRACT</h4> CTC1-STN1-TEN1 (CST) is a heterotrimeric, RPA-like complex that binds single-stranded DNA, stimulates DNA polymerase α-primase, and functions in several genome maintenance pathways, including telomere maintenance and DNA replication/repair. During telomere replication, CST prevents telomerase from overextending the G-rich single-stranded overhang (G-OH) and promotes fill-in of the C-rich strand...

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Literature Corpus work: 0bdeefb9-214d-5816-864b-cda5835526fe
DOI: 10.1101/2025.08.06.669015

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