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Article

Pol α-primase dependent nuclear localization of the mammalian CST complex.

Communications biology - 17 Mar 2021

Kelich Joseph M, Papaioannou Harry, Skordalakes Emmanuel

Abstract excerpt

The human CST complex composed of CTC1, STN1, and TEN1 is critically involved in telomere maintenance and homeostasis. Specifically, CST terminates telomere extension by inhibiting telomerase access to the telomeric overhang and facilitates lagging strand fill in by recruiting DNA Polymerase alpha primase (Pol α-primase) to the telomeric C-strand. Here we reveal that CST has a dynamic intracellular localization...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33731801
DOI: 10.1038/s42003-021-01845-4
PMCID: PMC7969954

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Pol α-primase dependent nuclear localization of the mammalian CST complex.PMID 33731801Read ↗

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