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Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres

17 Sept 2021

Abstract excerpt

Human shelterin components POT1 and TPP1 form a stable heterodimer that protects telomere ends from ATR-dependent DNA damage responses and regulates telomerase-dependent telomere extension. Mice possess two functionally distinct POT1 proteins. POT1a represses ATR/CHK1 DNA damage responses and the alternative non-homologous end-joining DNA repair pathway while POT1b regulates C-strand resection and recruits the...

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PMID: 34535663
DOI: 10.1038/s41467-021-25799-7

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