Back to search

Article

Neuronal Distribution of Tau Pathology, Microglial Gene Expression Trajectories, and Resilience to Alzheimer disease

2025-12-16

Abstract excerpt

<h4>Importance</h4> Some individuals are capable of tolerating Alzheimer disease neuropathological changes (ADNC) without manifesting clinical symptoms. Elucidating the neuropathological, and molecular mediators may facilitate the identification of more accurate in vivo biomarkers and inform the development of targeted therapeutic strategies. <h4>Objective</h4> To investigate cellular distribution of tau patho...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
dddd4028-0d87-54df-b7a0-bfc33570a414
DOI
10.64898/2025.12.15.25341752
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Neuronal Distribution of Tau Pathology, Microglial Gene Expression Trajectories, and Resilience to Alzheimer diseaseDOI 10.64898/2025.12.15.25341752
Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer’s disease reveals distinct sequential responses to Aβ and tauSemantic proximity
Changes in glial cell phenotypes precede overt neurofibrillary tangle formation, correlate with markers of cortical cell damage, and predict cognitive status of individuals at Braak III-IV stages.Semantic proximity
Neuroinflammation characterizes the earliest changes in Alzheimer’s disease pathology and associated subjective cognitive impairment in adult hydrocephalus biopsiesSemantic proximity
Whole-Brain Single-Neuron Atlas Reveals Microglial Security Hole Accelerating Neuronal VulnerabilitySemantic proximity
Alzheimer<sup>’</sup>s-associated inflammatory alterations mediate tau-associated neurodegeneration in limbic and temporal regions across clinical variants of Alzheimer<sup>’</sup>s diseaseSemantic proximity
Molecular properties underlying regional vulnerability to Alzheimer's disease pathology.Semantic proximity
Selective vulnerability and resilience to Alzheimer’s disease tauopathy as a function of genes and the connectomeSemantic proximity
Enhanced microglial dynamics and paucity of tau seeding in the amyloid plaque microenvironment contributes to cognitive resilience in Alzheimer’s diseaseSemantic proximity
Microglia-Associated Neuroinflammation in Alzheimer’s DiseaseSemantic proximity
Selective vulnerability and resilience to Alzheimer's disease tauopathy as a function of genes and the connectomeSemantic proximity
Novel Pathological Mechanisms Revealed by Spatial Transcriptomic Analysis of Hippocampus in Aged Control, Primary Age-Related Tauopathy, and Alzheimer’s DiseaseSemantic proximity
Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypesSemantic proximity
Select a neighboring publication to make it the new centre.