Genome-wide meta-analyses identifies novel taxane-induced peripheral neuropathy-associated loci.

doi:10.1097/FPC.0000000000000318

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Article

Genome-wide meta-analyses identifies novel taxane-induced peripheral neuropathy-associated loci.

Pharmacogenetics and genomics - 1 Feb 2018

Sucheston-Campbell Lara E, Clay-Gilmour Alyssa I, Barlow William E, Budd G Thomas, Stram Daniel O, Haiman Christopher A, Sheng Xin, Yan Li, Zirpoli Gary, Yao Song, Jiang Chen, Owzar Kouros, Hershman Dawn, Albain Kathy S, Hayes Daniel F, Moore Halle C, Hobday Timothy J, Stewart James A, Rizvi Abbas, Isaacs Claudine, Salim Muhammad, Gralow Jule R, Hortobagyi Gabriel N, Livingston Robert B, Kroetz Deanna L, Ambrosone Christine B

Abstract excerpt

OBJECTIVE: Taxane containing chemotherapy extends survival for breast cancer patients. However, taxane-induced peripheral neuropathy (TIPN) cannot be predicted, prevented or effectively treated. Using genome-wide analyses, we sought to identify common risk variants for TIPN. PATIENTS AND METHODS: Women with high-risk breast cancer enrolled in SWOG 0221 were genotyped using the Illumina 1M chip. Genome-wide...

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PMID: 29278617
DOI: 10.1097/FPC.0000000000000318
PMCID: PMC5824720

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GNGT1

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