Clinical and Genome-Wide Analysis of Cisplatin-Induced Peripheral Neuropathy in Survivors of Adult-Onset Cancer.

doi:10.1158/1078-0432.CCR-16-3224

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Article

Clinical and Genome-Wide Analysis of Cisplatin-Induced Peripheral Neuropathy in Survivors of Adult-Onset Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2017

Dolan M Eileen, El Charif Omar, Wheeler Heather E, Gamazon Eric R, Ardeshir-Rouhani-Fard Shirin, Monahan Patrick, Feldman Darren R, Hamilton Robert J, Vaughn David J, Beard Clair J, Fung Chunkit, Kim Jeri, Fossa Sophie D, Hertz Daniel L, Mushiroda Taisei, Kubo Michiaki, Einhorn Lawrence H, Cox Nancy J, Travis Lois B

Abstract excerpt

Purpose: Our purpose was to characterize the clinical influences, genetic risk factors, and gene mechanisms contributing to persistent cisplatin-induced peripheral neuropathy (CisIPN) in testicular cancer survivors (TCSs).Experimental Design: TCS given cisplatin-based therapy completed the validated EORTC QLQ-CIPN20 questionnaire. An ordinal CisIPN phenotype was derived, and associations with age, smoking, excess...

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PMID: 28611204
DOI: 10.1158/1078-0432.CCR-16-3224
PMCID: PMC5626588

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