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Article

Whole genome sequencing across clinical trials identifies rare coding variants in GPR68 associated with chemotherapy induced peripheral neuropathy

2022-07-13

Abstract excerpt

<title>Abstract</title> <p>Dose-limiting toxicities significantly impact the benefit/risk profile of many drugs. Whole genome sequencing (WGS) in patients receiving drugs with dose-limiting toxicities can identify therapeutic hypotheses to prevent these toxicities. Peripheral neuropathy (PN) is a common dose-limiting neurological toxicity of chemotherapies with no effective approach for prevention. We conducted a...

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Literature Corpus work
5ae66efc-6802-5ae9-9392-260ba90c330c
DOI
10.21203/rs.3.rs-1816977/v1
Open publication

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Whole genome sequencing across clinical trials identifies rare coding variants in GPR68 associated with chemotherapy induced peripheral neuropathyDOI 10.21203/rs.3.rs-1816977/v1
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