Article

Multidimensional mutational phenotypes of MMR deficiency in human cancer cells

2026-07-10

Abstract excerpt

Mismatch repair deficiency (MMRd) is a central driver of cancer genome evolution, yet it is commonly reduced to a binary MSI-high versus microsatellite-stable call. Here we combine multiplex CRISPR/Cas12a editing, long-term mutation accumulation experiments in human cells, and whole-genome sequencing to map the mutational consequences of single and pairwise perturbations across canonical and accessory MMR genes, t...

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Literature Corpus work: 98c1f3c7-415b-5d84-948f-8f7f11e31f54
DOI: 10.64898/2026.07.07.736851

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