Article

Tropomyosin 1 deficiency facilitates cell state transitions to enhance hemogenic endothelial cell specification during hematopoiesis

2023-09-02

Abstract excerpt

Tropomyosins coat actin filaments and impact actin-related signaling and cell morphogenesis. Genome-wide association studies have linked Tropomyosin 1 ( TPM1 ) with human blood trait variation. Prior work suggested that TPM1 regulated blood cell formation in vitro, but it was unclear how or when TPM1 affected hematopoiesis. Using gene-edited induced pluripotent stem cell (iPSC) model systems, TPM1 knockout wa...

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Literature Corpus work: 5393b9fa-9d08-5f78-8205-27b549ecefd4
DOI: 10.1101/2023.09.01.555861

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