Article

Tropomyosin 1 promotes platelet adhesion and clot contraction separate from its roles in developmental hematopoiesis

2025-08-02

Abstract excerpt

Genome-wide associations studies (GWAS) have linked the Tropomyosin 1 ( Tpm1 ) gene locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin-binding protein that stabilizes actin filaments and influences cell adhesion, signaling, and actomyosin contractility. Murine Tpm1 deficiency enhances embryonic hemogenic endothelial cell specification, but it was unclear if t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1dab898d-e053-5f10-8cbd-817817f845bc
DOI: 10.1101/2025.07.31.667883

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tropomyosin 1 promotes platelet adhesion and clot contraction separate from its roles in developmental hematopoiesisDOI 10.1101/2025.07.31.667883Read

Tropomyosin 1 deficiency facilitates cell state transitions to enhance hemogenic endothelial cell specification during hematopoiesisSemantic proximity Read

Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopeniaSemantic proximity Read

ACTN1 mutations cause congenital macrothrombocytopenia.Semantic proximity Read

Megakaryocyte Cytoskeletal Proteins in Platelet Biogenesis and DiseasesSemantic proximity Read

Megakaryocyte migration defects due to nonmuscle myosin IIA mutations underlie thrombocytopenia in MYH9-related disease.Semantic proximity Read

Rare missense variants in Tropomyosin‐4 (TPM4) are associated with platelet dysfunction, cytoskeletal defects, and excessive bleedingSemantic proximity Read

<i>Tropomyosin 1</i> genetically constrains <i>in vitro</i> hematopoiesisSemantic proximity Read

A circle of life: platelet and megakaryocyte cytoskeleton dynamics in health and disease.Semantic proximity Read

Hidden Complexity of Pediatric Platelet Disorders: Functional Diversity and Unexpected Hypercoagulable PhenotypesSemantic proximity Read

Downregulation of TREM-like transcript-1 and collagen receptor α2 subunit, two novel RUNX1-targets, contributes to platelet dysfunction in familial platelet disorder with predisposition to acute myelogenous leukemiaSemantic proximity Read

Inherited thrombocytopenias: the beat goes on.Semantic proximity Read

The Importance of Alpha-Actinin Proteins in Platelet Formation and Function, and Their Causative Role in Congenital Macrothrombocytopenia.Semantic proximity Read