Article

<i>Tropomyosin 1</i> genetically constrains <i>in vitro</i> hematopoiesis

2019-05-08

Abstract excerpt

Identifying causal variants and genes from human genetics studies of hematopoietic traits are important to enumerate basic regulatory mechanisms underlying these traits, and could ultimately augment translational efforts to generate platelets and/or red blood cells in vitro . To identify putative causal genes from these data, we performed computational modelling using available genome-wide association data sets f...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 824fb81c-cbfc-5f4f-9f2b-ade9e37d4bd3
DOI: 10.1101/631895

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Tropomyosin 1</i> genetically constrains <i>in vitro</i> hematopoiesisDOI 10.1101/631895Read

Tropomyosin 1 deficiency facilitates cell state transitions to enhance hemogenic endothelial cell specification during hematopoiesisSemantic proximity Read

Robust temporal map of human <i>in vitro</i> myelopoiesis using single-cell genomicsSemantic proximity Read

A pluripotent stem cell atlas of multilineage differentiation reveals <i>TMEM88</i> as a developmental regulator of mammalian blood pressureSemantic proximity Read

Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesisSemantic proximity Read

Generation of a human <i>Tropomyosin 1</i> knockout iPSC lineSemantic proximity Read

Multimodal analysis of <i>in vitro</i> hematopoiesis reveals blood cell-specific genetic impacts on complex disease traitsSemantic proximity Read

Tropomyosin 1 promotes platelet adhesion and clot contraction separate from its roles in developmental hematopoiesisSemantic proximity Read

RUNX1 haploinsufficiency causes a marked deficiency of megakaryocyte-biased hematopoietic progenitor cells: Mechanistic studies and drug correctionSemantic proximity Read

Modeling blood diseases with human induced pluripotent stem cellsSemantic proximity Read

The genetics of platelet count and volume in humansSemantic proximity Read

Integrating natural and engineered genetic variations to decode regulatory influence on blood traits.Semantic proximity Read

<i>rapunzel5</i> is necessary for normal hematopoietic development in zebrafishSemantic proximity Read