Article

Enhancing the anti-tumor efficacy of Bispecific T cell engagers via cell surface glycocalyx editing

2022-05-23

Abstract excerpt

Bispecific T-cell engager (BiTE)-based cancer therapies that activate the cytotoxic T cells of a patient’s own immune system have gained momentum with the recent FDA approval of Blinatumomab for treating B cell malignancies. However, this approach has had limited success in targeting solid tumors. Here, we report the development of BiTE-sialidase fusion proteins that enhance tumor cell susceptibility to BiTE-media...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5391ada9-56f6-5964-b81b-077a5f677d04
DOI: 10.1101/2022.05.22.492978

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Enhancing the anti-tumor efficacy of Bispecific T cell engagers via cell surface glycocalyx editingDOI 10.1101/2022.05.22.492978Read

Detecting Tumor Antigen-Specific T Cells via Interaction-Dependent Fucosyl-Biotinylation.Semantic proximity Read

Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockadeSemantic proximity Read

Generation of dual specific bivalent BiTEs (dbBIspecific T-cell Engaging antibodies) for cellular immunotherapySemantic proximity Read

Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and OpportunitiesSemantic proximity Read

Development of T-cell engagers selective for cells co-expressing two antigensSemantic proximity Read

A multifunctional T-cell engager containing CD80 enhances prostate cancer treatmentSemantic proximity Read

Tuning T-cell immunological synapse by modular DNA-Nanobody engagers for precision immunotherapySemantic proximity Read

A Simplified Function-First Method for the Discovery and Optimization of Bispecific Immune Engaging AntibodiesSemantic proximity Read

A nanobody-enzyme fusion protein targeting PD-L1 and sialic acid exerts anti-tumor effects by affecting tumor associated macrophagesSemantic proximity Read

Tumor sialylation controls effective anti-cancer immunity in breast cancerSemantic proximity Read

Reprogramming BCMA-Targeted CAR-T Cells through γ-Secretase Modulation Blocks Antigen Shedding and Extends CAR-T LongevitySemantic proximity Read

Single injection of modified self-amplifying RNA encoding a CD19 bispecific T cell engager mediates long-term malignant B cell clearanceSemantic proximity Read