Article
A Simplified Function-First Method for the Discovery and Optimization of Bispecific Immune Engaging Antibodies
2022-08-18
Abstract excerpt
Bi-specific T-cell engager antibodies (BITEs) are synthetic soluble molecules derived from antibodies that induce active contact between T-cells and other target cells in the body. BITE therapeutics have shown great promise for the treatment of various forms of cancer; however, the current development process for BITEs is time consuming and costly. BITE development requires empirical testing and characterization o...
Topics
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- CAR-T cell therapy research
- CRISPR and Genetic Engineering
- Immune Cell Function and Interaction
- Innovative Microfluidic and Catalytic Techniques Innovation
- Monoclonal and Polyclonal Antibodies Research
- Nanowire Synthesis and Applications
- Synthesis and Biological Evaluation
- Viral Infectious Diseases and Gene Expression in Insects
Identifiers and source
- Literature Corpus work
- 9662ab0c-7032-502d-82f4-039c16f19f99
- DOI
- 10.1101/2022.08.17.504342