Article

Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade

2021-04-11

Abstract excerpt

Immune checkpoint blockade (ICB) has significantly improved the prognosis of cancer patients, but the majority experience limited benefit, evidencing the need for new therapeutic approaches. Upregulation of sialic acid-containing glycans, termed hypersialylation, is a common feature of cancer-associated glycosylation, driving disease progression and immune escape via the engagement of Siglec-receptors on tumor-inf...

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Literature Corpus work: 38181a1a-1538-503e-a349-6a82d10e53ec
DOI: 10.1101/2021.04.11.439323

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