Article

A nanobody-enzyme fusion protein targeting PD-L1 and sialic acid exerts anti-tumor effects by affecting tumor associated macrophages

2024-06-09

Abstract excerpt

Cancer cells employ various mechanisms to evade immune surveillance. Their surface features, including a protective “sugar coat” and immune checkpoints like PD-L1 (programmed death ligand 1), can impede immune cell recognition. Sialic acids, which carry negative charges, may hinder cell contact through electrostatic repulsion, while PD-L1 transmits immunosuppressive signals to T cells. Furthermore, cancer cells ma...

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Literature Corpus work: 79b9d1ae-71dd-5d73-924b-ccef0dbaa564
DOI: 10.1101/2024.06.05.597674

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