Article

A multifunctional T-cell engager containing CD80 enhances prostate cancer treatment

2024-11-18

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>T-cell engagers (TCEs) are the most examined bispecific antibodies that recognize and target effector T cells to generate immune synapses against tumor cells, thereby resulting in T-cell activation and tumor killing. However, the inhibitory influence of the tumor microenvironment on TCEs' functionality has impeded their utilization in solid tumor therapies. To c...

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Literature Corpus work: 98baac24-35e1-5a82-8444-7704cc0cfec9
DOI: 10.21203/rs.3.rs-5391004/v1

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