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Article

Detecting Tumor Antigen-Specific T Cells via Interaction-Dependent Fucosyl-Biotinylation.

Cell - 12 Nov 2020

Liu Zilei, Li Jie P, Chen Mingkuan, Wu Mengyao, Shi Yujie, Li Wei, Teijaro John R, Wu Peng

Abstract excerpt

Re-activation and clonal expansion of tumor-specific antigen (TSA)-reactive T cells are critical to the success of checkpoint blockade and adoptive transfer of tumor-infiltrating lymphocyte (TIL)-based therapies. There are no reliable markers to specifically identify the repertoire of TSA-reactive T cells due to their heterogeneous composition. We introduce FucoID as a general platform to detect endogenous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33096019
DOI: 10.1016/j.cell.2020.09.048
PMCID: PMC7669731

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