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Article

Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities

28 Sept 2016

Abstract excerpt

Hypersialylation of tumor cell surface proteins along with a marked upregulation of sialyltransferase (ST) activity is a well-established hallmark of cancer. Due to the critical role of STs in tumor growth and progression, ST inhibition has emerged as a potential new antimetastatic strategy for a range of cancers including pancreatic and ovarian. Human STs are divided into subtypes based on their linkage and...

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PMID: 27678392
DOI: 10.1002/med.21407

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