Article

Reprogramming BCMA-Targeted CAR-T Cells through γ-Secretase Modulation Blocks Antigen Shedding and Extends CAR-T Longevity

2026-01-23

Abstract excerpt

B-cell maturation antigen (BCMA) shedding by γ-secretase generates soluble BCMA (sBCMA), which diminishes membrane antigen density, and limits the durability of BCMA-directed immunotherapies in multiple myeloma (MM). Here, using AI-driven diffusion modeling, we identify peptide inhibitors that selectively block γ-secretase–mediated BCMA cleavage, stabilizing membrane-bound BCMA (mBCMA) without compromising cellula...

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Literature Corpus work: dd91412a-0806-542a-9692-ce332d2e04c6
DOI: 10.64898/2026.01.20.700575

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