Article

Single injection of modified self-amplifying RNA encoding a CD19 bispecific T cell engager mediates long-term malignant B cell clearance

2026-04-19

Abstract excerpt

Bispecific T cell engagers (BiTEs) are a novel cancer immunotherapy modality that achieves significant clinical success. However, conventional single-chain variable fragment (scFv)-based BiTE therapy requires continuous intravenous infusion due to BiTE’s short half-life, limiting patient access and increasing healthcare cost. Self-amplifying RNA (saRNA), an emerging RNA technology, enables durable protein producti...

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Literature Corpus work: 36a625af-b08e-5fec-998f-bb96f43686a6
DOI: 10.64898/2026.04.18.719371

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