Article

Torques within and outside the human spindle balance twist at anaphase

2023-12-10

Abstract excerpt

At each cell division, nanometer-scale motors and microtubules give rise to the micron-scale spindle. Many mitotic motors step helically around microtubules in vitro, and most are predicted to twist the spindle in a left-handed direction. However, the human spindle exhibits only slight global twist, raising the question of how these molecular torques are balanced. Here, using lattice light sheet microscopy, we fin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 53646cb5-807d-590f-bf0e-2c814e437e3a
DOI: 10.1101/2023.12.10.570990

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Torques within and outside the human spindle balance twist at anaphaseDOI 10.1101/2023.12.10.570990Read

The mitotic spindle is chiral due to torques generated by motor proteinsSemantic proximity Read

Opposing motors provide mechanical and functional robustness in the human spindleSemantic proximity Read

Bayesian data driven modelling of kinetochore dynamics: space-time organisation of the human metaphase plateSemantic proximity Read

Human kinesin-5 KIF11 drives the helical motion of anti-parallel and parallel microtubules around each otherSemantic proximity Read

Coordinated poleward flux of sister kinetochore fibers drives chromosome alignmentSemantic proximity Read

Eg5 activity and density-driven bundling organize the human metaphase mitotic spindle independently of spindle bipolaritySemantic proximity Read

Insights into human outer kinetochore assembly and force transmission from a structure-function analysis of the KMN networkSemantic proximity Read

High-resolution imaging reveals how the spindle midzone impacts chromosome movementSemantic proximity Read

Force-transducing molecular ensembles at growing microtubule tips control mitotic spindle sizeSemantic proximity Read

Dynein-Dynactin-NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensemble.Semantic proximity Read

Computational modelling and near-complete kinetochore tracking reveal how chromosome dynamics during cell division are co-ordinated in space and timeSemantic proximity Read

A Universal Scaling Law for Mitotic Spindles Driven by Chromosome CrowdingSemantic proximity Read