Article

The mitotic spindle is chiral due to torques generated by motor proteins

2017-07-22

Abstract excerpt

Mitosis relies on forces generated in the spindle, a micro-machine composed of microtubules and associated proteins 1,2 . Forces are required for the congression of chromosomes to the metaphase plate and separation of chromatids in anaphase 3-6 . However, torques may also exist in the spindle, yet they have not been investigated. Here we show that the spindle is chiral. Chirality is evident from the finding that...

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Identifiers and source

Literature Corpus work: 76fc4688-02d1-577c-a2a6-c031111bd0f9
DOI: 10.1101/167437

Open publication

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