Article

A Universal Scaling Law for Mitotic Spindles Driven by Chromosome Crowding

2025-05-23

Abstract excerpt

<title>Abstract</title> <p>Cells regulate the size of their internal structures to maintain function in diverse biological settings<sup>1</sup>. The mitotic spindle, a molecular micro-machine responsible for chromosome segregation<sup>2</sup>, must scale to accommodate genomes varying in size by over 10,000-fold across eukaryotes<sup>3</sup>. Yet, how spindle biomechanics adapts to vastly different genome sizes r...

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Literature Corpus work: 82090df2-da1d-54c1-8233-bc91cad9d0f7
DOI: 10.21203/rs.3.rs-6194615/v1

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