Article

Human kinesin-5 KIF11 drives the helical motion of anti-parallel and parallel microtubules around each other

2023-08-04

Abstract excerpt

During mitosis, motor proteins and microtubule-associated protein organize the spindle apparatus by cross-linking and sliding microtubules. Kinesin-5 plays a vital role in spindle formation and maintenance, potentially inducing twist in the spindle fibers. The off-axis power stroke of kinesin-5 could generate this twist, but its implications in microtubule organization remain unclear. Here, we investigate 3D micro...

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Literature Corpus work: c96538cd-a25e-501f-b9c2-f637adad5ad3
DOI: 10.1101/2023.08.01.550848

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