Article

Eg5 activity and density-driven bundling organize the human metaphase mitotic spindle independently of spindle bipolarity

2026-01-16

Abstract excerpt

<h4>ABSTRACT</h4> The mitotic spindle segregates chromosomes through the coordinated actions of microtubules and molecular motors. Classic models propose that microtubules nucleate at spindle poles and grow inward to capture chromosomes; however, recent structural studies show that spindles contain short microtubules that do not span the distance between poles and chromosomes. It is unclear how these short microt...

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Literature Corpus work: 2522f7c5-2f0a-5fa7-804c-aaf9246e1044
DOI: 10.64898/2026.01.16.699769

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