Article

Opposing motors provide mechanical and functional robustness in the human spindle

2021-03-02

Abstract excerpt

<h4>Summary</h4> At each cell division, the spindle self-organizes from microtubules and motors. How the spindle’s diverse motors, often acting redundantly or in opposition, collectively give rise to its emergent architecture, mechanics, and function is unknown. In human spindles, the motors dynein and Eg5 generate contractile and extensile stress, respectively. Inhibiting dynein or its targeting factor NuMA lead...

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Literature Corpus work: 5c6c2337-4c69-533a-9c5e-3d2b7b9d32b0
DOI: 10.1101/2021.03.02.433652

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