Article

Mitochondrial DNA Variation in the D-LOOP and ND Loci identified in the Kenyan Population: Potential Implications for precision Oncology

2026-03-14

Abstract excerpt

<h4>Background</h4> Precision oncology is dominated by studies focused on nuclear genomic alterations, leaving mitochondrial DNA (mtDNA) variation excluded from routine clinical genomic testing. However, mitochondria regulate oxidative phosphorylation (OXPHOS), reactive oxygen species (ROS) production, apoptosis, and metabolic reprogramming pathways that are central to chemotherapy response. <h4>Methods</h4> 468...

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Literature Corpus work: 535ac5da-9f74-5681-83dd-76f141c17e43
DOI: 10.64898/2026.03.12.711313

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