Article

Mitochondrial DNA Mutations Determine Favourable Molecular Responses to Targeted Kinase Inhibitor Therapy and Impair Oxidative Phosphorylation

2025-07-18

Abstract excerpt

Somatic mutations in mitochondrial DNA (mtDNA) are not typically considered key oncogenic drivers of cancer, primarily because of a high synonymous to non-synonymous variant ratio. Here, we surveyed 248 matched diagnosis and remission samples from patients with chronic myeloid leukemia (CML) and found a 75% had mitochondrial mutations with a median number of 2 mutations per patient. mtDNA mutations were predominan...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6307a624-6b0b-5173-98d8-9369a8140b49
DOI: 10.1101/2025.07.15.664865

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial DNA Mutations Determine Favourable Molecular Responses to Targeted Kinase Inhibitor Therapy and Impair Oxidative PhosphorylationDOI 10.1101/2025.07.15.664865Read

Mitochondrial DNA alterations in precision oncology: Emerging roles in diagnostics and therapeutics.Semantic proximity Read

Respiratory complex and tissue lineage drive recurrent mutations in tumour mtDNA.Semantic proximity Read

Respiratory complex and tissue lineage drive mutational patterns in the tumor mitochondrial genomeSemantic proximity Read

Mitochondrial genome alterations in cancer: From mutations and epigenetics to targeted therapiesack.Semantic proximity Read

Deleterious heteroplasmic mitochondrial mutations increase risk of overall and cancer-specific mortalitySemantic proximity Read

Mitochondrial DNA is a major source of driver mutations in cancer.Semantic proximity Read

Deleterious heteroplasmic mitochondrial mutations are associated with an increased risk of overall and cancer-specific mortality.Semantic proximity Read

Mitochondrial metabolism as a target for acute myeloid leukemia treatmentSemantic proximity Read

Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis.Semantic proximity Read

Mitochondrial DNA Variation in the D-LOOP and ND Loci identified in the Kenyan Population: Potential Implications for precision OncologySemantic proximity Read

Somatic mtDNA Mutation Burden Shapes Metabolic Plasticity in LeukemogenesisSemantic proximity Read

Generation, function, and prognostic utility of somatic mitochondrial DNA mutations in cancer.Semantic proximity Read