Article

Deleterious heteroplasmic mitochondrial mutations increase risk of overall and cancer-specific mortality

2022-09-20

Abstract excerpt

<h4>Summary</h4> Mitochondria are involved in energetic, biosynthetic, and homeostatic processes in eukaryotic cells. Mitochondria carry their own circular genome and disruption of the quantity or quality of mitochondrial genome is associated with various aging-related diseases 1–3 . Unlike the nuclear genome, mitochondrial DNA (mtDNA) can be present at 1,000s to 10,000s copies in somatic cells and variants may ex...

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Literature Corpus work: b793098b-55db-5d37-932e-55e540f86072
DOI: 10.1101/2022.09.20.22280151

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